Novel, Fractionated Dosing Formulations for
Optimizing Titration of
Carbidopa/Levodopa
A Practical Roadmap for Improving Patient Satisfaction, Motor Symptoms,
Clinical Outcomes, and ON/OFF Time in Persons with PD
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"Off time” may vary in severity at different times during the day due to physical activity and other factors, does this support the need to have different dosing options available in the manner provided by a scored, fractionated formulation of CD/LD?
Can you please provide us with a brief summary of what you plan to cover in today’s CME program focusing on new advances in CD/LD-based treatment of PD, including the scored, fractionable dosing formulation of CD/LD?
Dr. Morgan, we’re pleased to have you presenting on this program on new advances and formulations of CD/LD with a special focus on “off time.” Can you provide us with a summary of topics you will cover on today’s CME program?
Once you commit to carbidopa/levodopa therapy, what is the typical starting dose, how long does it take for symptoms to ameliorate, and what should you expect in terms of long-term stability and/or deterioration (adverse fluctuations of ...
If you embark on a therapeutic transition from standard CD/LD to the scored, fractionable dosing formulation of CD/LD, exactly how do you advise or counsel the patient on a titration plan?
Once a patient is confirmed to have Parkinson’s Disease, what are the evidence- and guideline-based approaches to initiating pharmacotherapy and, sequencing therapy in cases that are refractory to initial therapy or that do not respond optimally?
What formulations for CD/LD are approved and available for PD, and for once a person with PD begins to experience significant “off time” on CD/LD. What is your approach to minimizing deterioration in clinical symptoms?
What is the role of fluctuating physical activity levels—hospital vs. rehab vs. home-based care—on the dose and dosing formulation of CD/LD and how does the CD/LD fractionable dosing formulation fit into the CD/LD titration equation?
What minimal diagnostic criteria or clinical symptom severity do you feel is required to be actionable for pharmacologic treatment in a person presenting with a sign-symptom complex suggestive of PD?